Steroids and insulin in septic shock – more data

In a multicentre RCT of patients with septic shock who were receiving steroids (hydrocortisone) for the septic shock, intensive insulin therapy did not affect outcome but was (once again) associated with a higher incidence of hypoglycaemia. Also, the addition of (enteral) fludrocortisone did not provide benefit compared with hydrocortisone alone.

Corticosteroid Treatment and Intensive Insulin Therapy for Septic Shock in Adults
JAMA. 2010;303(4):341-348