PPIs such as omeprazole affect the pharmacodynamics of thienopyridines such as clopidogrel, but this does not seem to affect clinical outcomes for most patients. Pantoprazole and esomeprazole have less of an effect on the platelet response to clopidogrel.
Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials
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