Misoprostol for PPH

Misoprostol is a prostaglandin analogue with uterotonic activity. It was compared with placebo in its sublingual form in a randomised trial in 1422 women with postpartum haemorrhage and uterine atony. It was given with other uterotonic agents (mostly oxytocin 10IU im or slow iv). The primary outcome was blood loss of 500 mL or more within 60 min after randomisation, and this was similar in both groups.
Misoprostol as an adjunct to standard uterotonics for treatment of post-partum haemorrhage: a multicentre, double-blind randomised trial
Lancet. 2010 May 22;375(9728):1808-13