A Systematic Review of Corticosteroids in the Treatment of Severe Sepsis and Septic Shock in Adults

This thorough review confirms that steroids have no clear benefit on mortality in severe sepsis / septic shock. Looking at prolonged courses of low dose steroids, there may be a beneficial effect but this did not reach statistical significance.
JAMA. 2009 Jun 10;301(22):2362-75
http://www.ncbi.nlm.nih.gov/pubmed/19509383

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