High-Dose N-Acetylcysteine Therapy for H1N1

A case report describes the improvement of a critically ill patient with H1N1 ‘flu after the administration of N-acetylcysteine in a dose similar to that used to treat paracetamol (acetaminophen) overdose.
Influenza virus induces reactive oxygen species that activate nuclear factor kappa B to produce cytokines. High-dose N-acetylcysteine, an antioxidant, is thought to reduce the production of this cytokine storm which contributes to the lethality of influenza. More studies are clearly needed.

High-Dose N-Acetylcysteine Therapy for Novel H1N1 Influenza Pneumonia
Ann Intern Med. 2010 May 18;152(10):687-8