An RCT of induced hypothermia to 33.5 degrees for 72 hours was undertaken in 625 newborns at least 36 weeks gestation who had evidence of asphyxial encephalopathy.
The intervention (hypothermia) group had improved scores in mental, psychomotor, and gross motor function and a reduced risk of cerebral palsy. There was an increased rate of survival without neurological abnormality. Overall survival was not different between groups.
Moderate hypothermia to treat perinatal asphyxial encephalopathy
N Engl J Med. 2009 Oct 1;361(14):1349-58