This Canadian multi-centre study on 65 children compared vasopressin infusions with placebo in children with vasodilatory shock who had already received fluid resuscitation and catecholamine infusions. No significant difference was observed in the primary endpoint of time to haemodynamic stability or the secondary endpoints of mortality, organ-failure–free days, length of critical care unit stay, and adverse events, although there was a trend toward increased mortality in the vasopressin group.
Vasopressin in Pediatric Vasodilatory Shock
Am J Respir Crit Care Med. 2009 Oct 1;180(7):632-9