NICE has issued guidance on this procedure for patients with acute liver failure.
“The procedure removes toxins bound to albumin in the blood in addition to the water-soluble toxins that can be removed by haemodialysis.”
They state that current evidence on its efficacy is inadequate in quality and quantity, and recommend the procedure “should only be used with special arrangements for clinical governance, consent and audit or research.”
Guidance summary here
Category Archives: All Updates
GI kit for GU disease
A Sengstaken-Blakemore tube may be used to control post-partum haemorrhage by placing it in the uterus. More information in this post
Obstetric & Gynaecology Guidelines
The Royal College of Obstetricians and Gynaecologists publishes a number of up to date evidence -based guidelines. Several are relevant to the resuscitation doctor and are well worth a look.
RCOG Guidelines Link
Life threatening post partum haemorrhage
A mother may experience life-threatening haemorrhage after delivery of her baby. What can the resuscitation doctor do?
Rosen’s Emergency Medicine describes four main differential diagnoses: uterine atony, genital tract trauma, retained placental tissue, and coagulopathies, or the “four Ts”: tone, trauma, tissue, and thrombin.
As well as resuscitation with fluid and blood products and urgent obstetric and anaesthetic referral, efforts should be made to restore uterine tone with manual and pharmacological means, and consider tamponade of the haemorrhage.
The MOET (Management of Obstetric Emergencies & Trauma) Course outlines the following interventions for major obstetric haemorrhage:
- Empty uterus: deliver fetus if undelivered / remove placenta or retained products (this may need to be done digitally according to Rosen)
- Oxytocin / ergometrine / prostaglandin
- Massage & bimanual compression of uterus
- Repair genital tract injury
- Uterine packing or Rusch balloon
- Compression of aorta
- Surgical or interventional radiological options: internal iliac or uterine artery ligation, hysterectomy, arterial embolisation
A review of the different balloon tamponade devices available describes the urological Rusch balloon, the dedicated Bakri balloon, a condom sutured to a Foley catheter, multiple Foley catheters, and the Sengstaken-Blakemore tube (SBT). In order for the SBT balloon to reach the uterine fundus, either the tip of the catheter can be cut and the gastric balloon inflated, or the SBT can be folded and the oesophageal balloon inflated. Normal saline is used to inflate the balloon until tamponade is achieved. If the cervix is dilated, vaginal packing may be necessary to prevent migration of the balloon out of the uterus..
The Royal College of Obstetricians and Gynaecologists published 2009 guidelines on PPH. The full text is available here. After commencing resuscitation, summoning help, considering the ‘four T’s’, and examining the patient they recommend:
- Bimanual uterine compression (rubbing up the fundus) to stimulate contractions.
- Ensure bladder is empty (Foley catheter, leave in place).
- Syntocinon 5 units by slow intravenous injection (may have repeat dose).
- Ergometrine 0.5 mg by slow intravenous or intramuscular injection (contraindicated in women with hypertension).
- Syntocinon infusion (40 units in 500 ml Hartmann’s solution at 125 ml/hour) unless fluid restriction is necessary.
- Carboprost 0.25 mg by intramuscular injection repeated at intervals of not less than 15 minutes to a maximum of 8 doses (contraindicated in women with asthma).
- Direct intramyometrial injection of carboprost 0.5 mg (contraindicated in women with asthma), with responsibility of the administering clinician as it is not recommended for intramyometrial use.
- Misoprostol 1000 micrograms rectally.
Balloon tamponade may then be attempted in cases of uterine atony pending surgical haemostasis if necessary.
As with all life-threatening emergencies, the resuscitation doctor should have a plan, and know his or her options regarding personnel, facilities and equipment. We recommend a closer look at the articles and guidelines referenced above in formulating your own plan as to how you might save a young mother’s life.
Spinal Cord Injury Guidelines
The Paralyzed Veterans of America produce a number of evidence-based guidelines for management of spinal cord injury and its complications that may be useful for the critical care doctor, downloadable from here.
The most relevant to frontline professionals is the Early Acute Management in Adults with Spinal Cord Injury: A Clinical Practice Guideline for Health-Care Professionals. A summary of the major recommendations from this document can be found here.
Which 'flu mask for staff?
A Canadian study in which 446 nurses were randomised to wear one or the other showed a standard surgical mask to be non-inferior to a N95 mask in preventing flu infection in the health workers.
Surgical Mask vs N95 Respirator for Preventing Influenza Among Health Care Workers
JAMA. 2009 Nov 4;302(17):1865-71
Prone positioning in ARDS
Prone positioning did not improve outcome in a randomised trial of 342 adult patients with ARDS.
Prone Positioning in Patients With Moderate and Severe Acute Respiratory Distress Syndrome
JAMA. 2009;302(18):1977-1984 Full Text
Pre-hospital intubation for head injury: ?no benefit
A systematic review of pre-hospital intubation for head injured patients failed to show evidence of benefit of tracheal intubation or invasive ventilation. The authors acknowledge the lack of methodological quality in the studies reviewed and the predominance of US paramedic-delivered intubations without the use of anaesthetic drugs.
Pre-hospital tracheal intubation in patients with traumatic brain injury: systematic review of current evidence
Br J Anaesth. 2009 Sep;103(3):371-86
Pre-hospital intubation 'success' at a US centre
Of 203 patients attending a US Level 1 trauma centre who had pre-hospital airway management, 25 (12%) had unrecognised oesophageal intubations.
Patients were treated in the field by fire rescue personnel of various municipalities and with different experience levels. Patients transported by air were significantly more likely to be successfully intubated than those transported by ground, perhaps due to both increased experience and the use by air crews of succinylcholine. The authors in their discussion contrast these results with those of European studies which report higher success rates with pre-hospital systems that employ emergency physicians and anaesthetists.
Prehospital intubations and mortality: a level 1 trauma center perspective
Anesth Analg. 2009 Aug;109(2):489-93
Vehicle Rollover
Vehicle rollover as an indicator of mechanism of injury was investigated in a study examining accident databases and the medical literature. Only 2.4% of crashes involved rollovers but they accounted for one third of occupant deaths.
Some facts on vehicle rollover from the article:
- Rollover is defined as a vehicle overturned by at least one quarter turn (at least onto its side).
- Some rollovers involve many quarter turns and the final resting position may be on the vehicle’s side, roof, or back on its wheels.
- Factors that cause a vehicle to roll over include trajectory (i.e., turning vs. straight), vehicle type, and speed (precrash velocity may be the most predictive factor)
The importance of vehicle rollover as a field triage criterion
J Trauma. 2009 Aug;67(2):350-7