Blood pressure target in septic shock
A study comparing mean arterial pressure (MAP) targets of 80 to 85 mm Hg (high-target group) with 65 to 70 […]
Acute Med, All Updates, ICU, Resus
vasoactive drugs
Acute Med, All Updates, Guidelines, ICU, Resus
No Benefit From Early Goal Directed Therapy
The first of three major trials assessing early goal directed therapy (EGDT) in sepsis – the American ProCESS Trial – […]
Acute Med, All Updates, ICU, Resus
Sepsis research – let's get some answers
There’s so much debate on which components of Early Goal Directed Therapy in sepsis really make a difference. The good […]
Acute Med, All Updates, ICU, Resus
Beta blockers potentially beneficial in septic shock
Counterintuitive as it sounds, this is pretty cool. I blogged about these guys before when they published their findings on […]
Acute Med, All Updates, ICU, Resus
Beta blockade in sepsis
What do septic patients need if they remain shocked after fluid resuscitation? Catecholamines right? Let’s stimulate some adrenoceptors and support […]
Acute Med, All Updates, ICU, Resus
Potential new therapy for acute heart failure
Interesting new drug to know about: Serelaxin, recombinant human relaxin-2. It’s hard to assess the clinical significance of the statistically […]
Acute Med, All Updates, ICU, Resus
Decatecholaminization in septic shock
A subset of patients from the 2008 Vasopressin and Septic Shock Trial (VASST) trial had invasive haemodynamic monitoring measurements from […]
Acute Med, All Updates, ICU, Resus
Nitrate bolus in acute heart failure
Despite intravenous nitrate boluses being used in original studies demonstrating benefit in acute heart failure1,2, I regularly meet reluctance from […]
All Updates, ICU, Resus
Phentolamine for neurogenic pulmonary oedema
A single case report might not be practice changing, but it’s helpful to know about this option: A patient with […]
Acute Med, All Updates, ICU, Resus
Dobutamine for severe heart failure – more harm than good?
A systematic review and meta-analysis of randomised controlled trials showed dobutamine is not associated with improved mortality in heart failure […]