Peripheral vasoactive infusions
It is often recommended that vasoactive agents are infused via central lines because of the risk of infiltration and tissue […]
All Updates, ICU, Kids, PHARM, Resus
vasoactive drugs
All Updates, ICU, Kids, Resus
Terlipressin for refractory cardiac arrest in kids
Okay so it’s a small case series – but the results warrant further investigation: 10-20 mcg/kg terlipressin was given to […]
All Updates, ICU, Resus
EGDT sepsis bundle challenged
An article in American Journal of Emergency Medicine by two intensivists challenges the science behind Rivers’ early goal-directed therapy (EGDT) […]
Acute Med, All Updates, ICU, Resus
Lactate clearance goal in sepsis
Previous work in severe sepsis/septic shock patients has shown that a decrease in lactate concentration by at least 10% during […]
All Updates, ICU, Resus
Noradrenaline vs Dopamine in Shock
Another nail in dopamine’s coffin? In a blinded randomised controlled trial in shocked patients1, there was no difference in mortality […]
Acute Med, All Updates, Resus
Levosimendan in beta blocker overdose
Not a human study, but toxicology RCTS rarely are… Levosimendan – a calcium sensitiser with inotropic properties, was superior to […]
All Updates, ICU, Resus
Effect on noradrenaline on tissue oxygen delivery
Some persist in thinking and teaching that the ‘vasopressor’ noradrenaline (norepinephrine) increases mean arterial pressure (MAP) simply by increasing systemic […]
All Updates, ICU, Kids, PHARM, Resus
Neonatal prostaglandin E1 and apnoea
The risk of apnoea in neonates requiring prostaglandin E1 infusions for duct-dependent congenital heart disease is well described and often […]