A very comprehensive (hence the title of the paper) review of medications required for pre-hospital & retrieval medicine missions was undertaken, resulting in recommendations. While the casemix seen by various services may be influenced by local geography or tasking restrictions, the list provides an excellent standard from which locally appropriate modifications can be made.
Defining a standard medication kit for prehospital and retrieval physicians: a comprehensive review.
Emerg Med J. 2010 Jan;27(1):62-71
Category Archives: All Updates
Appendicitis policy
The American College of Emergency Physicians has produced a policy entitled: ‘Critical Issues in the Evaluation and Management of Emergency Department Patients With Suspected Appendicitis‘
It contains the following questions and recommendations:
1. Can clinical findings be used to guide decisionmaking in the risk stratification of patients with possible appendicitis?
Level B recommendations. In patients with suspected acute appendicitis, use clinical findings (ie, signs and symptoms) to risk-stratify patients and guide decisions about further testing (eg, no further testing, laboratory tests, and/or imaging studies), and management (eg, discharge, observation, and/or surgical consultation).
2. In adult patients with suspected acute appendicitis who are undergoing a CT scan, what is the role of contrast?
Level B recommendations. In adult patients undergoing a CT scan for suspected appendicitis, perform abdominal and pelvic CT scan with or without contrast (intravenous [IV], oral, or rectal). The addition of IV and oral contrast may increase the sensitivity of the CT scan for the diagnosis of appendicitis.
3. In children with suspected acute appendicitis who undergo diagnostic imaging, what are the roles of CT and ultrasound in diagnosing acute appendicitis?
Level B recommendations.
1. In children, use ultrasound to confirm acute appendicitis but not to definitively exclude acute appendicitis.
2. In children, use an abdominal and pelvic CT to confirm or exclude acute appendicitis.
Level C recommendations. Given the concern over exposing children to ionizing radiation, consider using ultrasound as the initial imaging modality. In cases in which the diagnosis remains uncertain after ultrasound, CT may be performed.
The full document contains a helpful summary of existing literature on clinical scoring systems and laboratory investigations, including positive and negative likelihood ratios for various tests.
Trauma Report
England’s National Audit Office has published ‘Major Trauma Care in England’ recommendations. Summary is available here
ScvO2 in sepsis: high is bad too
ScvO2 values are obtained by measuring the oxygen saturation in venous blood returning to the heart, and reflect the balance between oxygen delivery and oxygen consumption.
Low (<70%) ScvO2 values were targeted by Rivers in his Early Goal Directed Therapy study: by improving the macrocirculation with fluids, vasoactive drugs, and packed red cells the aim is to improve oxygen delivery to tissues, and therefore a higher oxygen saturation is found in the venous blood returning to the heart in adequately resuscitated patients. The story is more complex, however, as mechanisms of oxygen supply (macrocirculatory flow), distribution (microcirculatory flow), and processing (mitochondrial function) must all function at an adequate level to maintain normal physiology.
Although low ScvO2 values may be a marker for macrocirculatory failure, high ScvO2 values may reflect microcirculatory or mitochondrial failure.
A multicentre study demonstrated a higher mortality on patients whose ScvO2 in the ED was high (90-100%) compared with those with a normal ScvO2.
Mortality associated with three groups according to their highest recorded ScvO2 in the ED was:
Hypoxia group (ScvO2 <70%) – 40% mortality (95% CI 29-53)
Normoxia group (ScvO2 71-89%) – 21% mortality (95% CI 17-25)
Hyperoxia group (ScvO2 90-100%) – 34% mortality (95% CI 25-44)
The study design could not control for many potential confounders, but this opens the door for further study, and reminds us that the unthinking pursuit of a single physiological target may miss the bigger clinical picture.
Multicenter Study of Central Venous Oxygen Saturation (ScvO2) as a Predictor of Mortality in Patients With Sepsis
Annals of Emergency Medicine 2010;55(1):40-46
80 lead ECG increases AMI detection – so what?
The 80-lead ECG is more sensitive than a 12 lead ECG for detecting infarcts in the posterior, right, inferior, and high lateral areas of the heart.
80-lead ECG body surface mapping was applied to 1830 patients in the emergency department with moderate to high risk chest pain. 12 lead ECG detected STEMI in 91 patients and an additional 25 patients had 80-lead-only STEMI.
The authors and an editorialist point out some interesting issues and unanswered questions regarding the application of this technology:
- Since almost all of the 80-lead-only STEMI patients had an elevated troponin, is this just another way of diagnosing NSTEMI?
- Since there are no convincing data demonstrating a benefit from immediate therapy of NSTEMI, would the earlier detection improve outcome?
- Angiographic findings in the 80-lead-only STEMI group showed similar lesions to 12-lead STEMI patients, with more frequent involvement of posterior (left circumflex) and right ventricular (right coronary artery) regions
- Is the increase in sensitivity offered by the 80-lead ECG accompanied by a decrease in specificity?
More research is needed – preferably in a randomised controlled trial – before this interesting technology is rolled out in emergency departments
Acute detection of ST-elevation myocardial infarction missed on standard 12-Lead ECG with a novel 80-lead real-time digital body surface map: primary results from the multicenter OCCULT MI trial.
Ann Emerg Med. 2009 Dec;54(6):779-788
The 80-lead ECG: more expensive NSTEMI or Occult STEMI
Ann Emerg Med. 2009 Dec;54(6):789-90
Levosimendan in beta blocker overdose
Not a human study, but toxicology RCTS rarely are…
Levosimendan – a calcium sensitiser with inotropic properties, was superior to dobutamine and to saline placebo in the end points of survival, cardiac output, and mean arterial pressure in anaesthetised pigs with propranolol overdose.
Levosimendan as a Rescue Drug in Experimental Propranolol- Induced Myocardial Depression: A Randomized Study
Ann Emerg Med. 2009 Dec;54(6):811-817
ABCD2 evaluated
Investigators evaluated in admitted patients with transient ischemic attack, the accuracy of the ABCD2 (age [A], blood pressure [B], clinical features [weakness/speech disturbance] [C], transient ischemic attack duration [D], and diabetes history [D]) score in predicting ischemic stroke within 7 days.
Of 1667 patients admitted with TIA, 23% developed an ischaemic stroke within 7 days. ABCD2 scores were available in 1054 patients, in whom a low score (0-3) had a negative likelihood ratio for disabling ischaemic stroke with 7 days of 0.16 ((5% CI 0.04-0.64) and sensitivity of 92.2% (83.4-96.5)
The authors suggest the best application of the ABCD2 score may be to identify patients at low risk for an early disabling ischemic stroke.
A multicenter evaluation of the ABCD2 score’s accuracy for predicting early ischemic stroke in admitted patients with transient ischemic attack.
Ann Emerg Med. 2010 Feb;55(2):201-210
ABCD2 Score Calculator
External jugular vein a tricky one
Emergency medicine residents and paramedics cannulated patients who were anaesthetised. The external jugular vein (EJV) took longer to cannulate and had a higher failure rate than an antecubital vein. More than a quarter of the paramedics and a third of the doctors failed to cannulate the EJV.
Is external jugular vein cannulation feasible in emergency care? A randomised study in open heart surgery patients
Resuscitation. 2009 Dec;80(12):1361-4
IO in OI
A case report describes three failed attempts to flush or secure an intraosseous needle placed using the EZ-IO drill during cardiac arrest of an adult patient subsequently noted to have osteogenesis imperfecta (OI) type III. While not listed as a contraindication to EZ-IO use by the manufacturer, one should consider that OI may result in procedural failure.
Intraosseous access in osteogenesis imperfecta (IO in OI)
Resuscitation. 2009 Dec;80(12):1442-3
HEMS paramedic intubation success
All medical out of hospital cardiac arrests attended by the Warwickshire and Northamptonshire Air Ambulance (WNAA) over a 64-month period were reviewed. There were no significant differences in self-reported intubation failure rate, morbidity or clinical outcome between doctor-led and paramedic-led cases. The authors conclude that experienced paramedics regularly operating with physicians have a low tracheal intubation failure rate at out of hospital cardiac arrests, whether practicing independently or as part of a doctor-led team, and that this is likely due to increased and regular clinical exposure.
Can experienced paramedics perform tracheal intubation at cardiac arrests? Five years experience of a regional air ambulance service in the UK
Resuscitation. 2009 Dec;80(12):1342-5