A very large nationwide Japanese observational study examined outcomes in out-of-hospital cardiac arrest patients who received CPR from lay rescuers. They compared conventional CPR (with mouth-to-mouth and chest compressions) with compression-only CPR. Over 40 000 patients were included.
Conventional CPR was associated with better outcomes than chest compression only CPR, for both one month survival (adjusted odds ratio 1.17, 95% confidence interval 1.06 to 1.29) and neurologically favourable one month survival (1.17, 1.01 to 1.35). Neurologically favourable one month survival decreased with increasing age and with delays of up to 10 minutes in starting CPR for both conventional and chest compression only CPR. The benefit of conventional CPR over chest compression only CPR was significantly greater in younger people in non-cardiac cases (P=0.025) and with a delay in start of CPR after the event was witnessed in non-cardiac cases (P=0.015) and all cases combined (P=0.037).
The authors conclude that conventional CPR is associated with better outcomes than chest compression only CPR for selected patients with out of hospital cardiopulmonary arrest, such as those with arrests of non-cardiac origin and younger people, and people in whom there was delay in the start of CPR.
Outcomes of chest compression only CPR versus conventional CPR conducted by lay people in patients with out of hospital cardiopulmonary arrest witnessed by bystanders: nationwide population based observational study
BMJ 2011; 2011; 342:c7106 Full Text
Tag Archives: ACLS
Improved survival with modified CPR
A large randomised controlled trial1 on out-of-hospital cardiac arrest patients compared standard CPR with CPR augmented by two modifications:
- active compression-decompression using a hand-held suction device to compress the chest. The device is attached to the chest of the patient during CPR and the rescuer actively lifts the chest upwards after each compression, which are done at a rate of 80/min
- augmented negative intrathoracic pressure using an impedance threshold device, which is a valve that limits passive air entry into the lungs during chest compressions, thereby reducing intrathoracic pressure and increasing blood flow to vital organs
The primary study endpoint was survival to hospital discharge with favourable neurological function.
Funding issues resulted in premature cessation of the study. 47 (6%) of 813 controls survived to hospital discharge with favourable neurological function compared with 75 (9%) of 840 patients in the intervention group (odds ratio 1·58, 95% CI 1·07–2·36; p=0·019]. 74 (9%) of 840 patients survived to 1 year in the intervention group compared with 48 (6%) of 813 controls (p=0·03), with equivalent cognitive skills, disability ratings, and emotional-psychological statuses in both groups. The overall major adverse event rate did not differ between groups, but more patients had pulmonary oedema in the intervention group (94 [11%] of 840) than did controls (62 [7%] of 813; p=0·015).
An accompanying editorial2 points out that previous studies in animal models of cardiac arrest gave reassuring results for both devices individually and when used together, but results from clinical trials in patients have been mixed for each device when used individually:
- For compression-decompression CPR, a systematic review pooled the existing data for such CPR versus standard CPR in 4162 patients and found no difference in short-term mortality (relative risk 0·98, 95% CI 0·94–1·03) or survival to hospital discharge (0·99, 0·98–1·01). The 2010 CPR guidelines for the USA and Europe do not recommend the use of compression–decompression CPR alone.
- The most current systematic review for the impedance-threshold device showed a significantly improved early survival (relative risk 1·45, 1·16–1·80), and a short-term improved neurological outcome (2·35, 1·30–4·24); however, improved long- term survival did not reach conventional statistical significance (1·48, 0·91–2·41).
The Resuscitation Outcomes Consortium (ROC) PRIMED study3 showed no survival benefit in 8718 patients randomised to standard CPR with an active or sham impedance-threshold device (the Consortium includes the same investigators as the Lancet paper). This was published as an abstract in Circulation recently.
The editorialist has reservations regarding a change in clinical practice resulting from this new study, partly because the trial was stopped prematurely and enrolment of a larger cohort could have changed the findings, and partly because the open use of both devices might have unintentionally introduced bias into the study. Further validation is recommended.
1. Standard cardiopulmonary resuscitation versus active compression-decompression cardiopulmonary resuscitation with augmentation of negative intrathoracic pressure for out-of-hospital cardiac arrest: a randomised trial
Lancet 2011;377:301-11
2. Augmented CPR: rescue after the ResQ trial
Lancet. 2011 Jan 22;377:276-7
3. The Resuscitation Outcomes Consortium ROC) PRIMED Impedance Threshold Device (ITD) Cardiac Arrest Trial: A Prospective, Randomized, Double-Blind, Controlled Clinical Trial
Circulation 2010; 122: 2215–26 (abstr)
VF on echo
How can you not love those guys at hqmeded.com?
Here’s a great case of theirs demonstrating the echocardiographic appearance of ventricular fibrillation – something we talk about on the BEAM course.
Australasian resus guidelines
Australian and New Zealand resuscitation councils have now revealed their resuscitation guidelines for adults and children. The index of guidelines can be found here
The Australian Resuscitation Council Online Index of Guidelines December 2010
Swimming the Channelopathy
Drowning is one of the leading causes of accidental death in children. Some apparent drownings may be related to sudden cardiac death, in particular to unidentified channelopathies, which are known to precipitate fatal arrhythmias during swimming-related events.
The majority of cases of sudden cardiac death in children and adolescents are secondary to either hypertrophic or right ventricular cardiomyopathy with coronary artery abnormalities also prevalent, and reports have demonstrated these cardiac abnormalities on autopsy following sudden swimming-related deaths.
However, the majority of autopsies in swimming-related sudden deaths are normal suggesting causation at molecular level, in particular ion channel defects such as type 1 long-QT syndrome (LQT1) and catecholaminergic polymorphic ventricular tachycardia (CPVT).
Some recommendations are made in an article in Archives of Disease in Childhood:
Proposed implementations to improve detection and appropriate management of apparent drownings secondary to cardiac channelopathies
- Improving awareness in the coronial service of the possibility of a cardiac cause for poorly explained drownings.
- Education of lifeguards and provision of automated defibrillators in swimming pools.
- Molecular autopsy for non-survivors to look for potential channelopathies.
- Screening for survivors and family members of non-survivors to identify those with a channelopathy.
- Proper counselling for those identified to have a channelopathy on family screening.
Drowning and sudden cardiac death
Arch Dis Child 2011;96:5-8
Passive leg raising during CPR
Measuring end-tidal carbon dioxide (ET CO2 ) is a practical non-invasive method for detecting pulmonary blood flow, reflecting cardiac output and thereby the quality of CPR. It has also been shown to rise before clinically detectable return of spontaneous circulation (ROSC).
Passive leg raising (PLR) increases venous return and may therefore augment cardiac output and in a cardiac arrest this may be reflected by an elevation in ETCO2.
A Swedish observational study of 126 patients with out of hospital cardiac arrest due to a likely cardiac aetiology underwent tracheal intubation with standardised ventilation and chest compressions (either manually or using the LUCAS device, as part of larger study of mechanical chest compressions according to a cluster design). Patients were stratified to receive either PLR to 20 degrees or no PLR. ETCO2 was measured during CPR, either for 15min, or until the detection of ROSC.
During PLR, an increase in ETCO2 was found in all 44 patients who received PLR within 15s (p=0.003), 45s (p = 0.002) and 75 s (p = 0.0001). Survival to hospital discharge was 7% among patients with PLR and 1% among those without PLR (p = 0.12). Among patients experiencing ROSC (60 of 126), there was a marked increase in ETCO2 1 min before the detection of a palpable pulse.
Passive leg raising during cardiopulmonary resuscitation in out-of-hospital cardiac arrest—Does it improve circulation and outcome?
Resuscitation. 2010 Dec;81(12):1615-20
CAB rather than ABC
The 2010 ILCOR resuscitation guidelines were published today. Key changes and continued points of emphasis from the 2005 BLS Guidelines include the following:
- Sequence change to chest compressions before rescue breaths (CAB rather than ABC)
- Immediate recognition of sudden cardiac arrest based on assessing unresponsiveness and absence of normal breathing (ie, the victim is not breathing or only gasping)
- “Look, Listen, and Feel” removed from the BLS algorithm
- Encouraging Hands-Only (chest compression only) CPR (ie, continuous chest compression over the middle of the chest) for the untrained lay-rescuer
- Health care providers continue effective chest compressions/CPR until return of spontaneous circulation (ROSC) or termination of resuscitative efforts
- Increased focus on methods to ensure that high-quality CPR (compressions of adequate rate and depth, allowing full chest recoil between compressions, minimizing interruptions in chest compressions and avoiding excessive ventilation) is performed
- Continued de-emphasis on pulse check for health care providers
- A simplified adult BLS algorithm is introduced with the revised traditional algorithm
- Recommendation of a simultaneous, choreographed approach for chest compressions, airway management, rescue breathing, rhythm detection, and shocks (if appropriate) by an integrated team of highly-trained rescuers in appropriate settings
2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Part 5: Adult Basic Life Support
Circulation. 2010;122:S685-S705
http://circ.ahajournals.org/cgi/content/full/122/18_suppl_3/S685
New CPR Guidelines
The International Liaison Committee on Resuscitation has published its five-yearly update of resuscitation guidelines.
The American Heart Association Guidelines can be accessed here
The European Resuscitation Guidelines can be accessed here
2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science
Circulation. 2010;122:S639
Pre-hospital cooling post arrest
An Australian randomised controlled trial assessed the effect of pre-hospital cooling (using 2 litres ice cold Hartmann’s) of post-cardiac arrest patients on functional status at hospital discharge. The intervention group were marginally cooler on arrival but did not have improved outcomes.
The authors conclude: In adults who have been resuscitated from out-of-hospital cardiac arrest with an initial cardiac rhythm of ventricular fibrillation, paramedic cooling with a rapid infusion of large-volume, ice-cold intravenous fluid decreased core temperature at hospital arrival but was not shown to improve outcome at hospital discharge compared with cooling commenced in the hospital.
Induction of Therapeutic Hypothermia by Paramedics After Resuscitation From Out-of-Hospital Ventricular Fibrillation Cardiac Arrest
Circulation. 2010 Aug 17;122(7):737-42 Free Full Text
One issue from this study was that relatively short urban pre-hospital transport times meant some patients did not get the full two litres, and some had already received room temperature fluids during the cardiac arrest resuscitation. The authors suggest further study should involved initiating cooling during the arrest. In fact a European study has done just that, using a device call a RhinoChill (a portable transnasal cooling device) to lower temperature during arrest in a randomised controlled trial. This trial showed pre-hospital intra-arrest transnasal cooling is safe and feasible and is associated with a significant improvement in the time intervals required to cool patients.
Intra-arrest transnasal evaporative cooling: a randomized, prehospital, multicenter study (PRINCE: Pre-ROSC IntraNasal Cooling Effectiveness)
Circulation. 2010 Aug 17;122(7):729-36
ETCO2 and ROSC
One for the ‘hardly surprising’ category….
A study of end-tidal CO2 during out-of-hospital adult and child cardiac arrest resuscitation showed a sudden rise in CO2 was associated with return of spontaneous circulation (ROSC), suggesting that witnessing this would be a good time for a pulse check. Data from the 59 patients who achieved ROSC are shown below, time zero being time of ROSC. There was no such observed rise in the 49 patients who did not achieve ROSC.
A Sudden Increase in Partial Pressure End-Tidal Carbon Dioxide (PETCO2) at the Moment of Return of Spontaneous Circulation
The Journal of Emergency Medicine, Vol. 38, No. 5, pp. 614–621, 2010