Category Archives: PHARM

Prehospital and Retrieval Medicine

Acute Med, All Updates, PHARM, Resus

Advanced airways and worse outcomes in cardiac arrest

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A new study demonstrates an association between advanced prehospital airway management and worse clinical outcomes in patients with cardiac arrest. Done in Japan, the numbers of patients included are staggering: this nationwide population-based cohort study included 658 829 adult patients. They found that CPR with advanced airway management (use of tracheal tubes and even supraglottic airways) was a significant predictor of poor neurological outcome compared with conventional bag-valve-mask ventilation.
Association of Prehospital Advanced Airway Management With Neurologic Outcome and Survival in Patients With Out-of-Hospital Cardiac Arrest
JAMA 2013;309(3):257-66
[EXPAND Click to read abstract]


Importance It is unclear whether advanced airway management such as endotracheal intubation or use of supraglottic airway devices in the prehospital setting improves outcomes following out-of-hospital cardiac arrest (OHCA) compared with conventional bag-valve-mask ventilation.

Objective To test the hypothesis that prehospital advanced airway management is associated with favorable outcome after adult OHCA.

Design, Setting, and Participants Prospective, nationwide, population-based study (All-Japan Utstein Registry) involving 649 654 consecutive adult patients in Japan who had an OHCA and in whom resuscitation was attempted by emergency responders with subsequent transport to medical institutions from January 2005 through December 2010.

Main Outcome Measures Favorable neurological outcome 1 month after an OHCA, defined as cerebral performance category 1 or 2.

Results Of the eligible 649 359 patients with OHCA, 367 837 (57%) underwent bag-valve-mask ventilation and 281 522 (43%) advanced airway management, including 41 972 (6%) with endotracheal intubation and 239 550 (37%) with use of supraglottic airways. In the full cohort, the advanced airway group incurred a lower rate of favorable neurological outcome compared with the bag-valve-mask group (1.1% vs 2.9%; odds ratio [OR], 0.38; 95% CI, 0.36-0.39). In multivariable logistic regression, advanced airway management had an OR for favorable neurological outcome of 0.38 (95% CI, 0.37-0.40) after adjusting for age, sex, etiology of arrest, first documented rhythm, witnessed status, type of bystander cardiopulmonary resuscitation, use of public access automated external defibrillator, epinephrine administration, and time intervals. Similarly, the odds of neurologically favorable survival were significantly lower both for endotracheal intubation (adjusted OR, 0.41; 95% CI, 0.37-0.45) and for supraglottic airways (adjusted OR, 0.38; 95% CI, 0.36-0.40). In a propensity score–matched cohort (357 228 patients), the adjusted odds of neurologically favorable survival were significantly lower both for endotracheal intubation (adjusted OR, 0.45; 95% CI, 0.37-0.55) and for use of supraglottic airways (adjusted OR, 0.36; 95% CI, 0.33-0.39). Both endotracheal intubation and use of supraglottic airways were similarly associated with decreased odds of neurologically favorable survival.

Conclusion and Relevance Among adult patients with OHCA, any type of advanced airway management was independently associated with decreased odds of neurologically favorable survival compared with conventional bag-valve-mask ventilation.

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All Updates, PHARM, Resus

Point of care analysis of intraosseous samples

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Some good news for remote, rural, prehospital, and retrieval medicine clinicians who rely on point of care testing with the i-STAT® device. An animal study confirmed the reliability of testing aspirates from intraosseous samples taken from the tibia(1).
This is also good news for hospital practitioners when it comes to the acquisition of blood gas results, since there are concerns over the potential damage to blood gas analysers by bone marrow contents in the samples.
The researchers tested blood gases, acid–base status, lactate, haemoglobin, and electrolytes, and compared these with results from an arterial sample.
There was no malfunction of the equipment. Most of the acid–base parameters showed discrepancies between arterial and osseous samples: the average pH and base excess were consistently lower whilst pCO2 and lactate were higher in the intraosseous samples compared to the arterial. However the overall small degree and predictable direction of discrepancy in these values should preserve the clinical usefulness of intraosseous gases if these findings can be replicated in human subjects. pO2 was obviously very different between osseous and arterial samples.
They noted that aspiration of intraosseous samples was generally straightforward, especially immediately after placement of the cannulae, but on a few occasions more forceful aspiration was needed. They point out that this could possibly cause cellular lysis and affect the potassium analysis.
The authors consider the issue of how much aspirate should be discarded before taking a sample after intraosseous cannula insertion, and refer to a prior study which suggested that 2mL is adequate.

Summary

  • Intraosseous aspirate can be tested on an i-STAT® point-of-care analyser
  • Haemoglobin and electrolytes show good correlation with arterial samples
  • Acid-base, pCO2, and lactate differ slightly from arterial results but in a predictable direction and results are still likely to be clinically useful in an emergency
  • It may be worth discarding the first 2 ml of aspirate
  • These results require validation in human subjects

Analysis of intraosseous samples using point of care technology–an experimental study in the anaesthetised pig
Resuscitation. 2012 Nov;83(11):1381-5
[EXPAND Click to read abstract]

BACKGROUND: Intraosseous access is an essential method in emergency medicine when other forms of vascular access are unavailable and there is an urgent need for fluid or drug therapy. A number of publications have discussed the suitability of using intraosseous access for laboratory testing. We aimed to further evaluate this issue and to study the accuracy and precision of intraosseous measurements.
METHODS: Five healthy, anaesthetised pigs were instrumented with bilateral tibial intraosseous cannulae and an arterial catheter. Samples were collected hourly for 6h and analysed for blood gases, acid base status, haemoglobin and electrolytes using an I-Stat point of care analyser.
RESULTS: There was no clinically relevant difference between results from left and right intraosseous sites. The variability of the intraosseous sample values, measured as the coefficient of variance (CV), was maximally 11%, and smaller than for the arterial sample values for all variables except SO2. For most variables, there seems to be some degree of systematic difference between intraosseous and arterial results. However, the direction of this difference seems to be predictable.
CONCLUSION: Based on our findings in this animal model, cartridge based point of care instruments appear suitable for the analysis of intraosseous samples. The agreement between intraosseous and arterial analysis seems to be good enough for the method to be clinically useful. The precision, quantified in terms of CV, is at least as good for intraosseous as for arterial analysis. There is no clinically important difference between samples from left and right tibia, indicating a good reproducibility.

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Acute Med, All Updates, Guidelines, ICU, PHARM, Resus

New STEMI guidelines

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Primary percutaneous coronary intervention or fibrinolysis for STEMI? What if you don’t have PCI at your hospital?
The new 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction is out and you can get the summary here.
Here’s what they say about initial reperfusion therapy:

Onset of Myocardial Infarction: Recommendations
Regional Systems of STEMI Care, Reperfusion Therapy, and Time-to-Treatment Goals
Class I
1. All communities should create and maintain a regional system of STEMI care that includes assessment and continuous quality improvement of emergency medical services and hospital-based activities. Performance can be facilitated by participating in programs such as Mission: Lifeline and the Door-to-Balloon Alliance.(Level of Evidence: B)
2. Performance of a 12-lead electrocardiogram (ECG) by emergency medical services personnel at the site of first medical contact (FMC) is recommended in patients with symptoms consistent with STEMI.(Level of Evidence: B)
3. Reperfusion therapy should be administered to all eligible patients with STEMI with symptom onset within the prior 12 hours. (Level of Evidence: A)
4. Primary PCI is the recommended method of reper- fusion when it can be performed in a timely fashion by experienced operators. (Level of Evidence: A)
5. Emergency medical services transport directly to a PCI-capable hospital for primary PCI is the recommended triage strategy for patients with STEMI, with an ideal FMC-to-device time system goal of 90 minutes or less.(Level of Evidence: B)
6. Immediate transfer to a PCI-capable hospital for primary PCI is the recommended triage strategy for patients with STEMI who initially arrive at or are transported to a non–PCI-capable hospital, with an FMC-to-device time system goal of 120 minutes or less.(Level of Evidence: B)
7. In the absence of contraindications, fibrinolytic therapy should be administered to patients with STEMI at non–PCI-capable hospitals when the anticipated FMC-to-device time at a PCI-capable hospital exceeds 120 minutes because of unavoidable delays.(Level of Evidence: B)
8. When fibrinolytic therapy is indicated or chosen as the primary reperfusion strategy, it should be administered within 30 minutes of hospital arrival.(Level of Evidence: B)
Class IIa
1. Reperfusion therapy is reasonable for patients with STEMI and symptom onset within the prior 12 to 24 hours who have clinical and/or ECG evidence of ongoing ischemia. Primary PCI is the preferred strategy in this population. (Level of Evidence: B)

2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: Executive Summary: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.
Circulation. 2012 Dec 17. [Epub ahead of print]

All Updates, ICU, Kids, PHARM, Resus, Trauma

Which pelvic compression device is best?

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Two popular pelvic compression devices are the SAM Pelvic Sling II and the T-POD®.
In a direct comparison 50 health care volunteers secured both devices correctly 100% of the time.
The SAM Pelvic Sling II was quicker to apply, but participants preferred the T-POD®.
The authors conclude that very little separates the devices.
Pelvic circumferential compression devices (PCCDs): a best evidence equipment review
Eur J Trauma Emerg Surg (2012) 38:439–442
[EXPAND Click for abstract]


Purpose Traumatic disruption of the pelvis can lead to significant morbidity and mortality. ATLS® guidance advocates temporary stabilisation or ‘closure’ of the disrupted pelvis with a compression device or sheet. We undertook a best evidence equipment review to assess the ease and efficacy of the application of two leading commercially available devices, the T-POD® and the SAM Pelvic Sling™ II.

Methods Fifty health care professionals and medical students participated in pelvic circumferential compression device (PCCD) education and assessment. Participants received a 10-min lecture on the epidemiology and aetiology of pelvic fractures and the principles of circumferential compression, followed by a practical demonstration. Three volunteers acted as trauma victims. Assessment included the time taken to secure the devices and whether this was achieved correctly. All participants completed a post-assessment survey.

Results Both devices were applied correctly 100% of the time. The average time taken to secure the SAM Pelvic Sling™ II was 18 s and for the T-POD®, it was 31 s (p ≤ 0.0001). Forty-four participants (88%) agreed or strongly agreed that the SAM Pelvic Sling™ II was easy to use compared to 84% (n = 42) for the T-POD®. Thirty-nine participants (78%) reported that they preferred and, given the choice in the future, would select the T-POD® over the SAM Pelvic Sling™ II (n = 11, 22%).

Conclusions The results of this study indicate that both PCCDs are easy and acceptable to use and, once learned, can be applied easily and rapidly. Participants applied both devices correctly 100% of the time, with successful application taking, on average, less than 60 s.

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All Updates, ICU, PHARM, Resus, Trauma, Ultrasound

What happened to HIFU?

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High intensity focused ultrasound (HIFU) was hailed as the ‘surgery of the future’ a few years ago(1). As it’s now the future, where is it?
HIFU uses ultrasound to increase the heat within tissues at a specific area, causing local necrosis and cautery without injuring surrounding tissues. It is used to treat some cancers, but has shown promise in haemorrhage control. In animal studies it reduced or stopped bleeding in liver(2), spleen(3), and vascular injuries(4).
It has been proposed to offer a promising method for hemorrhage control in both civilivan and miltary trauma(5). Automated systems have been developed and tested that identify bleeding using Doppler ultrasound techniques that then allow targeting of the HIFU beam to the bleeding tissue(6). The United States Army has identified the need for a such systems and has designed a remotely operated robotic haemostatic system to save lives of soldiers. This was presented in 2006(7).
I would love to know where we are with this technology, and why nothing seems to have appeared about it in the literature for the last few years. If you have any information, please fill us in via the comments box.
1. High intensity focused ultrasound: surgery of the future?
Br J Radiol. 2003 Sep;76(909):590-9 Full text
2. Liver hemostasis using high-intensity focused ultrasound
Ultrasound Med Biol. 1997;23(9):1413-20
3. Control of splenic bleeding by using high intensity ultrasound
J Trauma. 1999 Sep;47(3):521-5
4. Hemostasis of punctured blood vessels using high-intensity focused ultrasound
Ultrasound Med Biol. 1998 Jul;24(6):903-10
5. Hemorrhage control using high intensity focused ultrasound
Int J Hyperthermia. 2007 Mar;23(2):203-11
6. Focused ultrasound: concept for automated transcutaneous control of hemorrhage in austere settings.
Aviat Space Environ Med. 2009 Apr;80(4):391-4
7. Remotely Operated Robotic High Intensity Focused Ultrasound (HIFU) Manipulator System for Critical Systems for Trauma and Transport (CSTAT)
Presented at the IEEE Ultrasonics Symposium, October 3-6, 2006, Vancouver, Canada – Full Text Here

All Updates, Guidelines, ICU, PHARM, Resus, Trauma

Perimortem Caesarean Delivery: Late is Better than Not

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“To date, approximately one-third of the women who die during pregnancy remain undelivered at the time of death”

Guidelines recommend cardiac arrest in pregnant women beyond 20 weeks gestation should be treated with perimortem caesarean delivery (PMCD) commenced within 4 minutes of arrest and completed within 5. These time intervals come from two papers, neither of which is current or used robust review methodology.
To address this, an up-to-date fairly comprehensive review was undertaken of published cases of maternal cardiac arrests occurring prior to delivery. The primary outcome measures were maternal and neonatal survival to hospital discharge and the relationship between PMCD and this outcome.

The Arrests

94 cases were included in the final analysis.Most pregnancies were singleton (90.4%, n = 85) with an average gestational age at the time of the arrest of 33 ± 7 weeks (median 35, range 10–42).
The most common causes of arrest were trauma, maternal cardiac problems, severe pre-eclampsia and amniotic fluid embolism, together comprising about 70% of arrests; two thirds occurred in hospital.

The Outcomes

Overall, return of spontaneous circulation (ROSC) was achieved more often than not (60.6%) and overall survival to hospital discharge was 54.3%
Only 57 cases (75%) reported the time from arrest to delivery; the average time was 16.6 ± 12.5 min (median 10, range 1–60), with only 4 cases making it under the advocated 4-min time limit.

Timing of PMCD and Maternal Survival

In cases undergoing PMCD the average time elapsing from arrest to PMCD was significantly different between surviving (27/57) and non-surviving (30/57) mothers [10.0 ± 7.2 min (median 9, range 1–37) and 22.6 ± 13.3 min (median 20, range 4–60) respectively (p < 0.001, 95%CI 6.9–18.2)].

Timing of PMCD and Neonatal Survival

Mean times to PMCD were 14±11min (median=10, range=1–47) and 22 ± 13 min (median = 20, range = 4–60) in neonatal survivors and non-survivors respectively (p=0.016)
In cases with PMCD which reported outcome, the overall neonatal survival rate was 63.6% (42/66).


“The 4-min time frame advocated for PMCD usually remains unmet yet neonatal survival is still likely if delivery occurs within 10 or even 15 min of arrest”

Both maternal & neonatal mortality were higher with prehospital arrest location.

Summary

The study may be limited by recall bias, under-reporting and publication bias, but provides a more comprehensive evidence base on which to base resuscitation recommendations. The authors provide a useful warning against becoming fixated with the recommended four minute window, which may lead teams to fail to attempt a potentially life-saving intervention:


“Fixation on specific time frames for PMCD may not be ideal. It may be more important to focus on event recognition and good overall performance…. It may be wise to advocate a short time frame for performance of PMCD in order to achieve better outcomes; however, blanket endorsement of an unrealistic time frame may well create a defeatist attitude when that time frame cannot be met.”

Maternal cardiac arrest and perimortem caesarean delivery: Evidence or expert-based?
Resuscitation. 2012 Oct;83(10):1191-200
[EXPAND Click for abstract]


AIM: To examine the outcomes of maternal cardiac arrest and the evidence for the 4-min time frame from arrest to perimortem caesarean delivery (PMCD) recommended in current resuscitation and obstetric guidelines.

DATA SOURCES AND METHODS: Review and data extraction from all reported maternal cardiac arrests occurring prior to delivery (1980-2010). Cases were included if they provided details regarding both the event and outcomes. Outcomes of arrest were assessed using survival, Cerebral Performance Category (CPC) and maternal/neonatal harm/benefit from PMCD. Outcome measures were maternal and neonatal survival.

RESULTS: Of 1594 manuscripts screened, 156 underwent full review. Data extracted from 80 relevant papers yielded 94 included cases. Maternal outcome: 54.3% (51/94) of mothers survived to hospital discharge, 78.4% (40/51) with a CPC of 1/2. PMCD was determined to have been beneficial to the mother in 31.7% of cases and was not harmful in any case. In-hospital arrest and PMCD within 10 min of arrest were associated with better maternal outcomes (ORs 5.17 and 7.42 respectively, p<0.05 both). Neonatal outcome: mean times from arrest to delivery were 14±11 min and 22±13 min in survivors and non-survivors respectively (receiver operating area under the curve 0.729). Neonatal survival was only associated with in-hospital maternal arrest (OR 13.0, p<0.001).

CONCLUSIONS: Treatment recommendations should include a low admission threshold to a highly monitored area for pregnant women with cardiorespiratory decompensation, good overall performance of resuscitation and delivery within 10 min of arrest. Cognitive dissonance may delay both situation recognition and the response to maternal collapse.

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All Updates, ICU, PHARM, Resus, Trauma

London Calling – part 3

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Notes from Day 4 of the London Trauma Conference
The highlight for me was Mr Jonny Morrison speaking on Resuscitative Emergency Balloon Occlusion of the Aorta (REBOA). He is a British military surgeon currently out in Texas studying balloon occlusion of the aorta on pigs. Looking at trauma deaths, the next unexpected survivors will come from the uncontrollable haemorrhage group (truncal and junctional zones). This is by no means a new technique – described in the 1950’s during the Korean War – but like the early Star Wars chapters, needed to wait for technology to advance to make it feasible. It has the effect of cross clamping the aorta which provides afterload support, increases cerebral and coronary perfusion and provides proximal inflow control – without the mess of a resuscitative thoracotomy and greater access.
The placement of the balloon is determined by the location of the injury (see photo) and falls into two zones. Zone 1 is the thoracic aorta and is used for truncal haemorrhage control, avoid Zone 2 where the celiac axis etc originates and Zone 3 is infrarenal, used for junctional bleeding and pelvic haemorrhage.
His studies have determined that for Zone 3 amenable bleeds balloon occlusion up to 60min is the optimal time. Any longer and the debt of the metabolic load is paid by increased inotropic support requirements. He also compared REBOA to the current standard treatment for junctional injuries, Celox™ gauze. If coagulation is normal then both treatments perform similarly, the benefit is seen in coagulopathic patients where REBOA outperforms the gauze.
Has REBOA been used on humans? Yes a case series of 13 – the technique improved the BP allowing time to get to definitive surgery (blogged here 2.5 years ago!).
The Zone 1 studies are looking at continuous vs intermittent balloon occlusion. The jury is still out as to which is better. With the intermittent occlusion (20min on, 1min off) there are inevitably some losses when the balloon is deflated, conversely the metabolic debt generated by continuous occlusion is too great in some also leading to deaths.
What was very clear is that for this technique to have an impact it must be delivered proactively and pre-hospital. The challenges that need to be overcome are access to the femoral artery and blind accurate placement.
Prof Karim Brohi brought the conference to a close with a summary of what we have learned about coagulation in trauma this year. Here are three things;

  • FFP is good but as 43% deaths due to trauma in the UK are secondary to bleeding and occur in the first 3hr we are failing our patients by administering the treatment on average at 2.5hrs.
  • Fibrinogen levels are low in coagulopathic trauma patients; we should give cryoprecipitate early and aim for Fib ≥2.0
  • And finally whilst TEG is recommended to guide treatment and can provide results within 5 min, there are some aspects of coagulation it does not detect i.e. fibrinolysis was only detected in 8% of coagulopathic trauma patients – when measured in the plasma it was then detectable in 80%.

These are the highlights of the 2012 London Trauma Conference. I hope this whistle stop tour through these days has been informative and though provoking. I can assure you telephone hacking was not used to bring you this information and to my knowledge is correct.
This is Lou Chan, roving reporter for Resus ME! signing off.

 

 

‘London raises her head, shakes off the debris of the night from her hair, and takes stock of the damage done. The sign of a great fighter in the ring is can he get up from a fall after being knocked down… London does this every morning.’

 
 

All Updates, ICU, PHARM, Resus, Trauma

London Calling – part 2

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Notes from Days 2 & 3 of the London Trauma Conference
Day 2 of the LTC was really good. There were some cracking speakers who clearly had the ‘gift’ when it comes to entertaining the audience. No death by PowerPoint here (although it seems Keynote is now the presentation software of choice!). The theme of the day was prehospital care and major incidents.
The golden nuggets to take away include: (too many to list all of course)

  • ‘Pull’ is the key to rapid extrication from cars if time critical from the Norweigan perspective. Dr Lars Wik of the Norweigen air ambulance presented their method of rapid extrication. Essentially they drag the car back on the road or away from what ever it has crashed into to control the environment and make space (360 style). They put a paramedic in the car whilst this is happening. They then make a cut in the A post near the roof, secure the rear of the car to a fire truck or fixed object with a chain and put another chain around the lower A post and steering wheel that is then winched tight. This has the effect of ‘reversing’ the crash and a few videos showed really fast access to the patient. The car seems to peel open. As they train specifically for it, there doesn’t seem to be any safety problems so far and its much quicker than their old method. I guess it doesnt matter really how you organise a rapid extrication method as long as it is trained for and everyone is on the same page.
  • Dr Bob Winter presented his thoughts on hangings – to date no survivor of a non-judicial hanging has had a C-spine injury, so why do we collar them? Also there seems no point in cooling them. All imaging and concern for these patients should be based on the significant soft tissue injury that can be caused around the neck.
  • Drownings – if the patient is totally submerged probably reasonable to search for 30mins in water that is >6 degrees or 90mins if <6 degrees. After that it becomes a body recovery (unless there is an air pocket or some exceptional circumstance). Patients that have drowned should have early ventilatory support if they show any signs of resp distress.
  • Drs Julian Thompson and Mark Byers reassured us on a variety of safety issues at major incidents. It seems the risk to rescuers from secondary bombs at scene is low. Very few terrorist attacks world wide, ever, have had secondary devices so rescuers should be reassured (a bit). Greatest risk to the rescuer, like always, are the silly simple things that are a risk every day, like tripping over your own feet! With reference to chemical incidents, simple PPE seems to be sufficient for the vast majority of incidents, even fairly significant chemical ones, all this mucking about in full air tight suits is probably pointless and means patients cant be treated (at all). This led to the debate of how much risk should we, as rescue staff, accept? Clearly there are no absolute answers but minimising all risk to the rescuer is often at conflict with your ability to rescue. Where the balance should lie is a matter for organisations and individuals I guess.
  • Sir Prof Keith Porter also gave us an update on the future of Prehospital emergency medicine as a recognised medical specialty. As those in the know, know, the specialty has been recognised by the GMC and the first draft of trainees are currently in post. More deaneries will be following suit soon to begin training but it is likely to take some time to build up large numbers of trained specialists. Importantly for those of us who already have completed our training there will be an option to sub specialise in PHEM but it will involve undertaking the FIMC exam. Great, more exams – see you there.

 
Day 3 – Major trauma
The focus of day 3 was that of damage control. Damage control surgery and damage control resucitation. We had indepth discussions about how to manage pelvic trauma and some of the finer points of trauma resuscitation.
Specific points raised were:

  • Pelvic binders are great and can replace an ex fix if the abdomen needs opening to fix a spleen for example.
  • You can catheterise patients with pelvic fractures (one gentle try).
  • Most pelvic bleeds are venous which is why surgeons who can pack a pelvis is better than a radiologist who can mainly only treat arterial bleeds.
  • Coagulopathy in trauma is not DIC and is probably caused by peripheral hypoperfusion.
  • All the standard clotting tests that we use (INR etc) are useless and take too long to do. ROTEM or TEG is much better but still not perfect.

Also, as I am sure will please many – pressure isn’t flow so dont use pressors in trauma!
 
 


Chris Hill is an emergency and prehospital care physician based in the United Kingdom

All Updates, ICU, PHARM, Resus, Trauma, Ultrasound

London Calling!!

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Notes from Day 1 of the London Trauma Conference
I’ve always fancied trying my hand at journalism so when this opportunity to cover the London Trauma Conference (LTC) presented itself how could I resist? The LTC is well established now running into its sixth year. So what little gems does it have left to offer?
The Air Ambulance Symposium opened the conference with strong representation from Norway.
Dr Marius Rehn presented a thought provoking talk on pre-hospital trauma triage. Pragmatically there will always be a proportion of patients that are mistriaged. So is under triage worse than over triage? It depends on whose point of view you take. If you’re the trauma victim then under triage is your greatest fear. But as clinicians we display loyalty bias (preferential consideration for our current patient over those we have no involvement with) which leads to over triage. The consequences are usually unseen as they manifest in other areas of the health system – studies have demonstrated a detrimental effect in cardiac patients arriving in units where a trauma patient is treated concurrently. Commonly under triaged are older patients that have low mechanism falls and children involved in RTC’s are over triaged. Triage protocols aren’t perfect but those based on physiology and anatomy are the best; even better still an experienced clinician (physicians better than paramedics) and in the future we should think about using lactate clearance.
I have never needed any convincing that ultrasound has a role in pre-hospital care. However Dr Nils Petter Oveland presented some of his research (due for publication next year) which reinforces this belief. He studied chest ultrasound for the detection of pneumothoraces. Plain radiography interpreted by a consultant radiologist can detect a 500ml pneumothorax; ultrasonography can detect a mere 50ml. Using pig models he demonstrated a linear relationship between the volume of the pneumothorax and the sternal – lung point distance (lung point = where the lung edge remains in contact with the pleura). Practically how can we use this? A small pneumothorax may be detected by ultrasound but have no clinical consequence. Prior to aero medical transfer the lung point can be marked and if clinical deterioration occurs en route repeat US can accurately determine an increase in pneumothorax volume and guide treatment. Genius!
Prof Hans Morten Lossius provided a convincing argument for pre-hospital stroke thrombolysis. If you believe in this treatment, then it is more efficacious the sooner it is delivered (see photo). So why are we aiming for a thrombolysis time that is suboptimal? The thrombolysis times for a central Norwegian hospital were in the region of 3.5hrs, this reduced to 2.5hrs with rapid transportation. Approaching the problem from a different angle they trialled pre-hospital management with a mobile unit (CT scanner + neuroradiologist + neurologist) reducing time to thrombolysis to 72min (Lancet Neurology 2012, Walter). The next step is a multicentre RCT comparing standard treatment against a mobile CT + pre-hospital team with telemedical links to the Stroke centre……..
The Keynote address from Dr Gareth Davies took a look at the past and then a look to the future – the focus remained the same; providing the intervention patients need when they need it! Could this lead us into a future of Resuscitative Emergency Balloon Occlusion of the Aorta (REBOA) or Emergency Preservation Resuscitation (EPR) or emergency pre-hospital burr holes? Only time will tell.
Dr Steven Solid presented a double bill on patient safety. Admission to hospital is a high risk activity (as risky as bungee jumping!). Patient harm in aviation occurs 2 per 1000 flights. Only 25% were aviation related; mostly they are communication or equipment failures. He suggests medical line checks and team simulation training.

Dr Anne Weaver finished the first day with the story of her quest to get pre-hospital blood onto London HEMS to compliment the pre-hospital haemostatic resuscitation strategy they have for exsanguinating haemorrhage (tranexamic acid, prothrombin complex concentrate (for rapid warfarin reversal), POC INR machine, Buddy Lite™ blood warmers). Initial observations after the first six months are that ROSC is achieved more frequently in traumatic cardiac arrests although it’s too early to comment on mortality benefit. But this isn’t then end of the story – the next challenge is fresh frozen plasma.

All Updates, ICU, Kids, PHARM, Resus

Reassurance: difficult laryngoscopy in children remains rare

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I was taught a useful principle by a paediatric anaesthetist 10 years ago which has proven true in my experience and has contributed to keeping me calm when intubating sick kids. Unlike adults, in whom difficulty in intubation can often be unexpected, the vast majority of normal looking children are easy to intubate, and the ones who are difficult usually have obvious indicators such as dysmorphism.
This appears to be supported by recent evidence: in a large retrospective series of 11.219 anaesthesia patients, the overall incidence of difficult laryngoscopy [Cormack and Lehane (CML) grade III and IV] was only 1.35%, although was much higher in infants less than one year compared with older children. This low percentage is in the same ball park as two other paediatric studies. Besides younger age, their database suggested underweight, ASA III and IV physical status and, if obtainable, Mallampati III and IV findings as predictors for difficult laryngoscopy. The authors point out:

“…the oromaxillofacial surgery department with a high proportion of cleft palate interventions and pediatric cardiac surgery contributed substantially to the total number of difficult laryngoscopies. In patients undergoing pediatric cardiac surgery, a possible explanation for the higher incidence of CML III/IV findings might be that some congenital heart defects are associated with chromosomal anomalies like microdeletion 22q11.2 syndrome. This syndrome is also associated with extracardiac anomalies like cranio-facial dysmorphism“

Take home message: As a very rough rule of thumb to illustrate the difference between the ease/difficulty of laryngoscopy between adults and kids, I think it’s fair to say grade III or IV views occur in about 10% of adults but only about 1% of children.

Incidence and predictors of difficult laryngoscopy in 11.219 pediatric anesthesia procedures
Paediatr Anaesth. 2012 Aug;22(8):729-36
[EXPAND Click for abstract]


OBJECTIVE: Difficult laryngoscopy in pediatric patients undergoing anesthesia.

AIM: This retrospective analysis was conducted to investigate incidence and predictors of difficult laryngoscopy in a large cohort of pediatric patients receiving general anesthesia with endotracheal intubation.

BACKGROUND: Young age and craniofacial dysmorphy are predictors for the difficult pediatric airway and difficult laryngoscopy. For difficult laryngoscopy, other general predictors are not yet described.

METHODS: Retrospectively, from a 5-year period, data from 11.219 general anesthesia procedures in pediatric patients with endotracheal intubation using age-adapted Macintosh blades in a single center (university hospital) were analyzed statistically.

RESULTS: The overall incidence of difficult laryngoscopy [Cormack and Lehane (CML) grade III and IV] was 1.35%. In patients younger than 1 year, the incidence of CML III or IV was significantly higher than in the older patients (4.7% vs 0.7%). ASA Physical Status III and IV, a higher Mallampati Score (III and IV) and a low BMI were all associated (P < 0.05) with difficult laryngoscopy. Patients undergoing oromaxillofacial surgery and cardiac surgery showed a significantly higher rate of CML III/IV findings.

CONCLUSION: The general incidence of difficult laryngoscopy in pediatric anesthesia is lower than in adults. Our results show that the risk of difficult laryngoscopy is much higher in patients below 1 year of age, in underweight patients and in ASA III and IV patients. The underlying disease might also contribute to the risk. If the Mallampati score could be obtained, prediction of difficult laryngoscopy seems to be reliable. Our data support the existing recommendations for a specialized anesthesiological team to provide safe anesthesia for infants and neonates.

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