Category Archives: All Updates

Estimating child weight in Hong Kong

We know that the ‘APLS formula’ is inaccurate as a tool for estimating weight in Western children, and British and Australian researchers have devised more fitting formulae for their local populations as described here.

Summary table from the Hong Kong study of existing weight estimation rules

The emergency medicine team at the Accident and Emergency Medicine Academic Unit, Chinese University of Hong Kong have now provided a solution for Chinese children:

weight (kg) = (3 x age) + 5.

This was most accurate and precise in children <7 years old.
Age-based formulae to estimate children’s weight in the emergency department
Emerg Med J. 2010 Oct 13. [Epub ahead of print]

It gets tricky if they're 50% Chinese. Luckily, he's my son and I know how much he weighs.

GCS in intubated patients

We use the Glasgow Coma Score to describe conscious level, derived from eye opening, verbal response, and motor response.
One problem is that if your patient is intubated, there can’t be a verbal response. There are some ways round this. Imagine your intubated patient opens eys to a painful stimulus and withdraws his limb from one:

  • Just give him the lowest score (1) for the verbal component – E2M4V1
  • Write ‘V’ (ventilated) or ‘T’ (tube), eg. E2M4VT
  • Make it up, based on what you would expect the V score to be based on the E and M scores.

Weird as it sounds, there is a model for this, demonstrated in the paper abstracted below. The Derived Verbal Score = -0.3756 + Motor Score * (0.5713) + Eye Score * (0.4233).

Don’t worry…if you really want to use this, you don’t have to memorise that equation; there is an online calculator for it here and if you try it you’ll see this patient gets a derived verbal score of 2.3, and therefore a GCS of 7.3! Your decision now whether to round up or down. (In the meantime, I’ve given the patient a V of 1 and called it GCS E2M4VT=7.)
Alternatively, of course, you could try a better validated score that gives more information, the FOUR score, as validated here. The problem is, most people won’t know what you’re talking about.
The conundrum of the Glasgow Coma Scale in intubated patients: a linear regression prediction of the Glasgow verbal score from the Glasgow eye and motor scores.
Meredith W, Rutledge R, Fakhry SM, Emery S, Kromhout-Schiro S.
BACKGROUND: The Glasgow Coma Scale (GCS), which is the foundation of the Trauma Score, Trauma and Injury Severity Score, and the Acute Physiology and Chronic Health Evaluation scoring systems, requires a verbal response. In some series, up to 50% of injured patients must be excluded from analysis because of lack of a verbal component for the GCS. The present study extends previous work evaluating derivation of the verbal score from the eye and motor components of the GCS.
METHODS: Data were obtained from a state trauma registry for 24,565 unintubated patients. The eye and motor scores were used in a previously published regression model to predict the verbal score: Derived Verbal Score = -0.3756 + Motor Score * (0.5713) + Eye Score * (0.4233). The correlation of the actual and derived verbal and GCS scales were assessed. In addition the ability of the actual and derived GCS to predict patient survival in a logistic regression model were analyzed using the PC SAS system for statistical analysis. The predictive power of the actual and the predicted GCS were compared using the area under the receiver operator characteristic curve and Hosmer-Lemeshow goodness-of-fit testing.
RESULTS: A total of 24,085 patients were available for analysis. The mean actual verbal score was 4.4 +/- 1.3 versus a predicted verbal score of 4.3 +/- 1.2 (r = 0.90, p = 0.0001). The actual GCS was 13.6 + 3.5 versus a predicted GCS of 13.7 +/- 3.4 (r = 0.97, p = 0.0001). The results of the comparison of the prediction of survival in patients based on the actual GCS and the derived GCS show that the mean actual GCS was 13.5 + 3.5 versus 13.7 + 3.4 in the regression predicted model. The area under the receiver operator characteristic curve for predicting survival of the two values was similar at 0.868 for the actual GCS compared with 0.850 for the predicted GCS.
CONCLUSIONS: The previously derived method of calculating the verbal score from the eye and motor scores is an excellent predictor of the actual verbal score. Furthermore, the derived GCS performed better than the actual GCS by several measures. The present study confirms previous work that a very accurate GCS can be derived in the absence of the verbal component.
The conundrum of the Glasgow Coma Scale in intubated patients: a linear regression prediction of the Glasgow verbal score from the Glasgow eye and motor scores.
J Trauma. 1998 May;44(5):839-44 (if you have full text access to Journal of Trauma the best bit about this article is the discussion on pages 844-5 in which surgeons wrestle with the meaning of the word ‘conundrum’ and the spelling of ‘Glasgow’).

Flying Docs and Airways

Flying Doctor Minh Le Cong describes the profile and success rates of emergency endotracheal intubation conducted by the Queensland Royal Flying Doctor Service aeromedical retrieval team, comprising a doctor and flight nurse. It would be interesting to know how many more patients have been added to the registry since this was submitted. An important contribution to the literature in retrieval medicine.


Objective To describe the profile and success rates of emergency endotracheal intubation conducted by the Queensland Royal Flying Doctor Service aeromedical retrieval team comprising a doctor and flight nurse.

Method Each intubator completed a study questionnaire at the time of each intubation for indications, complications, overall success, drugs utilised and deployment of rescue airway devices/adjuncts.

Results 76 patients were intubated; 72 intubations were successful. None required surgical airway and three were managed with laryngeal mask airways; the remaining failure was managed with simple airway positioning for transport. There were two cardiac arrests during intubation. Thiopentone and suxamethonium were the predominant drugs used to facilitate intubation.

Conclusion Despite a low rate of endotracheal intubation, the high success rate was similar to other aeromedical organisations’ published airway data. This study demonstrates the utility of the laryngeal mask airway device in the retrieval and transport setting, in particular for managing a failed intubation.

Flying doctor emergency airway registry: a 3-year, prospective, observational study of endotracheal intubation by the Queensland Section of the Royal Flying Doctor Service of Australia
Emerg Med J. 2010 Sep 15. [Epub ahead of print]
Those interested in learning more about this registry, including how often capnography was used, more information about the asystolic arrests, and whether they tried a blind digital intubation, can check this link to a presentation about the registry.

How to give cold saline in the field

Pre-hospital therapeutic hypothermia might be a good thing, but there may be difficulties in achieving it if the 4 degrees C saline warms up during the infusion. What’s the optimal way of administering it? Czech investigators attempt to answer the question:
Background The cooling efficacy of intravenous administration of cold crystalloids can be enhanced by optimisation of the procedure. This study assessed the temperature stability of different application regimens of cold normal saline (NS) in simulated prehospital conditions.

Methods Twelve different application regimens of 4°C cold NS (volumes of 250, 500 and 1000 ml applied at infusion rates of 1000, 2000, 4000 and 6000 ml/h) were investigated for infusion temperature changes during administration to an artificial detention reservoir in simulated prehospital conditions.
Results An increase in infusion temperature was observed in all regimens, with an average of 8.163.38C (p<0.001). This was most intense during application of the residual 20% of the initial volume. The lowest rewarming was exhibited in regimens with 250 and 500 ml bags applied at an infusion rate of 6000 ml/h and 250 ml applied at 4000 ml/h. More intense, but clinically acceptable, rewarming presented in regimens with 500 and 1000 ml bags administered at 4000 ml/h, 1000 ml at 6000 ml/h and 250 ml applied at 2000 ml/h. Other regimens were burdened by excessive rewarming.
Conclusion Rewarming of cold NS during application in prehospital conditions is a typical occurrence. Considering that the use of 250 ml bags means the infusion must be exchanged too frequently during cooling, the use of 500 or 1000 ml NS bags applied at an infusion rate of $4000 ml/h and termination of the infusion when 80% of the infusion volume has been administered is regarded as optimal.
Prehospital cooling by cold infusion: searching for the optimal infusion regimen
Emerg Med J. 2010 Aug 23. [Epub ahead of print]

Inadequate pre-hospital needle thoracostomy

The purpose of this study was to evaluate the frequency of inadequate needle chest thoracostomy in the prehospital setting in trauma patients suspected of having a pneumothorax (PTX) on the basis of physical examination.
This study took place at a level I trauma center. All trauma patients arriving via emergency medical services with a suspected PTX and a needle thoracostomy were evaluated for a PTX with bedside ultrasound. Patients too unstable for ultrasound evaluation before tube thoracostomy were excluded, and convenience sampling was used. All patients were scanned while supine. Examinations began at the midclavicular line and included the second through fifth ribs. If no sliding lung sign (SLS) was noted, a PTX was suspected, and the lung point was sought for definitive confirmation. When an SLS was noted throughout and a PTX was ruled out on ultrasound imaging, the thoracostomy catheter was removed. Descriptive statistics were calculated.

Image used with kind permission of Bret Nelson, MD, RDMS (click image for more great ultrasound images)

A total of 57 patients were evaluated over a 3-year period. All had at least 1 needle thoracostomy attempted; 1 patient underwent 3 attempts. Fifteen patients (26%) had a normal SLS on ultrasound examination and no PTX after the thoracostomy catheter was removed. None of the 15 patients were later discovered to have a PTX on subsequent computed tomography.
In this study, 26% of patients who received needle thoracostomy in the prehospital setting for a suspected PTX appeared not to have had a PTX originally, nor had 1 induced by the needle thoracostomy. It may be prudent to evaluate such patients with bedside ultrasound instead of automatically converting all needle thoracostomies to tube thoracostomies.
Inadequate needle thoracostomy rate in the prehospital setting for presumed pneumothorax: an ultrasound study
J Ultrasound Med. 2010 Sep;29(9):1285-9

End tidal CO2 in cardiac arrest

Measuring end-tidal CO2 in cardiac arrest patients is helpful for

  1. confirming tracheal tube placement
  2. assessing the effectiveness of chest compressions
  3. predicting likelihood of return of spontaneous circulation (ROSC), in that a persistently low ETCO2 tends to predict death, whereas a high or rising ETCO2 is associated with a higher chance of ROSC.

It may be however that its predictive ability depends on the type of cardiac arrest, and how far into the resuscitation you’ve got when you measure the ETCO2. Consider this new study from Slovenian pre-hospital emergency physicians:
Methods: The study included two cohorts of patients: cardiac arrest due to asphyxia with initial rhythm asystole or pulseless electrical activity (PEA), and cardiac arrest due to arrhythmia with initial rhythm VF or pulseless VT. The causes of asphyxia were: asthma, severe acute respiratory failure, tumor of the airway, suicide by hanging, acute intoxication, pneumonia and a foreign body in the airway.PetCO2 was measured for both groups immediately after intubation and repeatedly every minute, both for patients with or without return of spontaneous circulation (ROSC). We compared the dynamic pattern of PetCO2 between groups. Resuscitation procedures were performed by an emergency medical team (emergency medical physician and two emergency medical technicians or registered nurses) in accordance with 2005 ERC Guideline
Results: Between June 2006 and June 2009 resuscitation was attempted in 325 patients and in this study we included 51 patients with asphyxial cardiac arrest and 63 patients with VF/VT cardiac arrest. The initial values of PetCO2 were significantly higher in the group with asphyxial cardiac arrest (6.74 ± 4.22 kilopascals (kPa) versus 4.51 ± 2.47 kPa; P = 0.004). In the group with asphyxial cardiac arrest, the initial values of PetCO2 did not show a significant difference when we compared patients with and without ROSC (6.96 ± 3.63 kPa versus 5.77 ± 4.64 kPa; P = 0.313). We confirmed significantly higher initial PetCO2 values for those with ROSC in the group with primary cardiac arrest (4.62 ± 2.46 kPa versus 3.29 ± 1.76 kPa; P = 0.041).

A significant difference in PetCO2 values for those with and without ROSC was achieved after five minutes of CPR in both groups (asphyxial arrest: 6.09 ± 2.63 kPa versus 4.47 ± 3.35 kPa; P = 0.006; primary arrest: 5.63 ± 2.01 kPa versus 4.26 ± 1.86; P = 0.015)
In mmHg, the PetCO2 values for those with and without ROSC after five minutes of CPR was: asphyxial arrest: 42.3 ± 20 mmHg versus 34 ± 25.5 mmHg; P = 0.006; primary arrest: 42.8 ± 15.3 mmHg versus 32.3 ± 14.1 mmHg; P = 0.015
Graphically, this difference in ROSC vs non-ROSC PetCO2 for both groups appeared to be even greater at ten minutes, with higher statistically significance (p<0.001), although the values of PetCO2 are not given in the paper.
In all patients with ROSC the initial PetCO2 was again higher than 1.33 kPa (10.1 mmHg).
Conclusions: The dynamic pattern of PetCO2 values during out-of-hospital CPR showed higher values of PetCO2 in the first two minutes of CPR in asphyxia, and a prognostic value of initial PetCO2 only in primary VF/VT cardiac arrest. A prognostic value of PetCO2 for ROSC was achieved after the fifth minute of CPR in both groups and remained present until final values. This difference seems to be a useful criterion in pre-hospital diagnostic procedures and attendance of cardiac arrest.
The authors summarise with the following key messages:

  • Initial values of PetCO2 are higher in asphyxial cardiac arrest than in primary cardiac arrest.
  • Initial values of PetCO2 in asphyxial cardiac arrest do not have a prognostic value for resuscitation outcome.
  • The prognostic value of PetCO2 for ROSC was achieved after the fifth minute of CPR in both groups and remained present until the final values.
  • The values of PetCO2 seem to be useful in differentiating the causes of cardiac arrest in a pre-hospital setting.

I think that last one’s a bit of a stretch. For me, this paper confirms that the longer you are into a cardiac arrest resuscitation, the worse news a low PetCO2 is. The lack of predictive value of initial PetCO2, particularly in the asphyxia group, is interesting but not surprising.
The dynamic pattern of end-tidal carbon dioxide during cardiopulmonary resuscitation: difference between asphyxial cardiac arrest and ventricular fibrillation/pulseless ventricular tachycardia cardiac arrest
Critical Care 2011, 15:R13

UK children sedation guideline

Despite the huge number of articles in the literature on paediatric sedation, one still encounters acrimonious debates about the appropriateness of non-anaesthetists doing it. How refreshing then, to see that the UK’s National Institute for Health & Clinical Excellence (“NICE”) has tackled this subject and come up with some reasonable recommendations. I’ve as yet only read the summary, but some of the good things are:

  • No unachievable ‘two doctors present’ rule: ‘Two trained healthcare professionals should be available during sedation
  • Differentiating painless imaging from painful procedures
  • Monitoring standards that are appropriate for the age of child and depth of sedation (no mandatory blood pressure or ECG monitoring unless deep sedation; end-tidal capnography in deep sedation).
  • Acknowledgement of the special features of ketamine: ‘Ketamine is a dissociative agent: the state of dissociative sedation cannot be readily categorised as either moderate or deep sedation; the drug is considered to have a wide margin of safety.’
  • Recognition that specialists other than anaesthetists may have specialist sedation and airway skills

There are some rather conservative recommendations on fasting, although the wording of the guideline in my interpretation allows some flexibility if ketamine is used for an emergency procedure.
Sedation in children and young people
National Institute for Health & Clinical Excellence

Propofol and the heart

I don’t normally blog about animal studies, but on reading a review of recent(-ish) shock research I was interested in the following piece that describes the effect of diffrent induction agents on rat heart muscle:
Sedation is frequently necessary in patients with septic shock, and therefore Zausig and colleagues investigated the effects of dose-dependent effects of various induction agents (propofol, midazolam, s(+)-ketamine, methohexitone, etomidate) in a Langendorff heart preparation from rats rendered septic by CLP. Propofol exerted the most pronounced depressant effects on both the maximal systolic contraction and the minimal diastolic relaxation, and cardiac work. Furthermore, propofol only adversely deleteriously affected the myocardial oxygen supply- demand ratio. In contrast, s(+)-ketamine was associated with the best maintenance of cardiac function. Within the limits of the study – that is, the use of an ex vivo isolated organ model – the authors concluded that s(+)-ketamine may be an alternative to the comparably inert etomidate, the use of which is, however, limited due to its endocrine side effects.

Of course we should be cautious about extrapolating animal lab work to clinical practice, but this supports my position of vehement opposition to the injudicious use of propofol for RSI in critically ill patients!
Year in review 2009: Critical Care – shock
Critical Care 2010, 14:239 Full text

Pre-hospital therapeutic hypothermia

A Czech study demonstrated effective pre-hospital therapeutic cooling of post-cardiac arrest patients using fairly modest amounts of intravenous saline at 4°C: the administration of 12.6 ± 6.4 mL/kg (1,032 ± 546 mL) of 4°C normal saline led to a tympanic temperature decrease of 1.4 ± 0.8°C (from 36.2 ± 1.5 to 34.7 ± 1.4°C; P < 0.001) in 42.8 ± 19.6 minutes. No ice packs were applied.

Before other emergency medical services adopt this, it should be noted that all these patients were managed in the field by emergency physicians who administered sedatives and neuromuscular blockers. It’s a European thing.
Pre-hospital cooling of patients following cardiac arrest is effective using even low volumes of cold saline
Critical Care 2010, 14:R231 Full text

Prone ventilation in ARDS

Prone ventilation can improve refractory hypoxaemia in ARDS but its effects on mortality have not been impressive in some studies which may be underpowered or include patients with less severe hypoxaemia. An updated meta-analysis showed significantly reduced ICU mortality in the four recent studies that enrolled only patients with ARDS, as opposed to ARDS/ALI (odds ratio = 0.71; 95% confidence interval = 0.5 to 0.99; P = 0.048; number needed to treat = 11). There may also be benefit from a greater duration of prone positioning.

An updated study-level meta-analysis of randomised controlled trials on proning in ARDS and acute lung injury
Critical Care 2011, 15:R6 Full text